NEWS: Wilson et al. 2023
April 27, 2023
Our paper on the technical development of svCapture - a novel approach to error correction and suppression in next generation sequencing optimized for detecting very rare structural variant junctions - has been accepted for publication in NAR Genomics and Bioinformatics.
The paper is currently available in preprint form on bioRxiv.
The approach builds on the concepts of Duplex Sequencing, developed at TwinStrand Biosciences, our collaborator on the project.
Success of the method depends on a carefully constructed data analysis pipeline made available as part of our SVX tool suite through the Michigan Data Interface (MDI).
Perhaps most importantly, the methods in the paper underlie a series of studies that comprise a manuscript in preparation regarding the cell cycle timing of structural variant formation.
Detecting aphidicolin-induced deletions by svCapture. Demonstration of the clear induction of structural variants above a low background signal, after error suppression and correction by svCapture.
Detecting aphidicolin-induced deletions by svCapture. Demonstration of the clear induction of structural variants above a low background signal, after error suppression and correction by svCapture.
