Funding Support

We are very grateful to all of our sponsors for the support we have received to pursue our work!

In particular, the United States National Institutes of Health (NIH) has been a critical supporter of biomedical research in my lab and well beyond, enabling the extensive discovery, technology development, and professional training that has advanced the lives of countless Americans and the world for decades.

Cell cycle timing and molecular mechanisms of structural variant formation following incomplete replication
NIH/NIGMS R01 GM147026-01 Recent News
04/12/2023 to 03/31/2027
Seeks to understand the molecular mechanisms of copy number variant (CNV) formation at common fragile sites (CFSs) - in follow up to NCI grant CA200731.
Tom Glover CNV Mechanisms Wilson et al. 2023 Wilson et al. 2024
Error-suppressed whole genome sequencing for genotoxicant-induced structural variant detection
NIH/NIEHS R21 ES034143-01 Recent News
07/14/2023 to 06/30/2026
The goal of this exploratory technology project is to develop sequencing approaches for detecting ultra-rare single-copy structural variant junctions in biological samples for genotoxcity and experimental applications.
Jeanmarie Mishler Joey Stewart CNV Mechanisms Penelope P2
Early events in double-strand break repair in local, genomic and metabolic contexts
NIH/NIGMS R01 GM120767-15 Recent News
08/01/2004 to 08/31/2026
Basic science studies of DNA double-strand break repair executed mainly via genetic approaches in the yeast model organism.
Mikael Dunn Mutation ID Yeast DSB Repair Bazzano et al. 2021 Chiruvella et al. 2013 Chiruvella et al. 2013 Chiruvella et al. 2014 Liang et al. 2016 Lomonaco et al. 2021 Moorthy et al. 2019 Song et al. 2014 Sunder et al. 2019 Wilson et al. 2020
Diversification of cortical function in health and disease via developmentally programmed deletions in large, brain-specific genes
UM/Research_Scouts Internal
06/01/2024 to 05/30/2025
We hypothesized for years that large brain-specific genes will harbor replication-stress-induced structural variants (SVs); this project aims to definitively determine the burden of such mutations using new error-suppressed whole genome sequencing approaches.
Jeanmarie Mishler Joey Stewart CNV Mechanisms Penelope P2
Single Cell Spatial Analysis Program
UM Biosciences_Initiatives Institutional SCSAP
02/01/2020 to 01/31/2026
UM investment to grow high resolution genomic and imaging approaches in cells and tissues through faculty recruitment, core facility development, and community engagement.
SCSAP
Extreme genomic instability at large transcribed genes: mechanisms and consequences for the cancer genome
NIH/NCI R01 CA200731-05 Recent News
09/01/2016 to 08/31/2022
Seeks to understand the molecular mechanisms of copy number variant (CNV) formation at common fragile sites (CFSs).
Tom Glover CNV Mechanisms Glover et al. 2017 Glover et al. 2020 Park et al. 2021 Wilson et al. 2015 Wilson et al. 2023
High throughput assessment of de novo CNV formation in eukaryotic cells
NIH/NIEHS R21 ES022311-02
08/06/2013 to 03/31/2016
Helped to develop novel methods for detecting CNVs and SVs at low variant allele frequencies at hotspot loci.
CNV Mechanisms
De novo CNV formation in vivo with sickle cell anemia therapy
NIH/NIEHS R01 ES020875-05
01/30/2012 to 05/31/2017
Tested whether in vivo exposure to a known replication inhibitor, hydroxyurea (HU), led to CNV formation in sperm.
CNV Mechanisms Arlt et al. 2018