NEWS: Wilson et al. 2022
July 7, 2022
We are thrilled to report our work on the technical development of svCapture, a novel approach to error correction and suppression in next generation sequencing optimized for detecting very rare structural variant junctions.
The approach builds on the concepts of Duplex Sequencing, developed at TwinStrand Biosciences, our collaborator on the project.
Success of the method depends on a carefully constructed data analysis pipeline made available as part of our SVX tool suite through the Michigan Data Interface (MDI).
Stay tuned for the journal submission of this work and its companion biological study, where we will use svCapture to explore the timing and mechanisms of chromosomal rearrangement formation at chromosome fragile sites.
Detecting aphidicolin-induced deletions by svCapture. Demonstration of the clear induction of structural variants above a low background signal, after error suppression and correction by svCapture.
Detecting aphidicolin-induced deletions by svCapture. Demonstration of the clear induction of structural variants above a low background signal, after error suppression and correction by svCapture.
